Casp8-Flox

Nomenclature

C57BL/6Smoc-Casp8em1(flox)Smoc

Cat. NO.

NM-CKO-190003

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Casp8

Synonyms

MACH， Mch5， FLICE， CASP-8

NCBI ID

12370

MGI ID

1261423

Ensembl ID

ENSMUSG00000026029

Pubmed

Casp8

Human Ortholog

CASP8

Model Description

These Casp8 flox mice possess loxP sites flanking exons 4. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.
Research Application：cancer research,Apoptosis

Disease Connection

Autoimmune Lymphoproliferative Syndrome Type 2B

Phenotype(s)

MGI:2655731
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lck-cre mice.

Reference(s)

Salmena L, Hakem R, Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder. J Exp Med. 2005 Sep 19;202(6):727-32

Atopic Dermatitis

Phenotype(s)

MGI:4888399
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with KRT14-cre mice.

Reference(s)

Li C, Lasse S, Lee P, Nakasaki M, Chen SW, Yamasaki K, Gallo RL, Jamora C, Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22249-54

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