Nkx3-1-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Nkx3-1em1(IRES-CreERT2)Smoc

Cat. NO.

NM-KI-200071

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Nkx3-1

Synonyms

Bax; NKX3A; NKX3.1; Nkx-3.1; bagpipe

NCBI ID

18095

MGI ID

97352

Ensembl ID

ENSMUSG00000022061

Pubmed

Nkx3-1

Human Ortholog

NKX3-1

Model Description

A IRES-CreERT2 expression cassette was knocked into the Nkx3-1 gene stop codon site.
Research Application：This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. This strain is useful in studying prostate.

Validation Data

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Fig. 1 CreERT2-mediated recombination in the prostate of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the prostate lumen cells of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

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Fig. 2 Detection of tdTomato(red) in various tissues of Nkx3-1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. Tdtomato was expressed in the prostate and individual cells of kidney. TdTomato can not be detected in the brain, thymus, retina, lung, liver, stomach, salivary gland, pancreas, colon, intestine, spleen, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)


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