Slc17a6-IRES-Cre

Nomenclature

C57BL/6Smoc-Slc17a6em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200087

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Slc17a6

Synonyms

DNPI; VGLUT2; 2900073D12Rik

NCBI ID

140919

MGI ID

2156052

Ensembl ID

ENSMUSG00000030500

Pubmed

Slc17a6

Human Ortholog

SLC17A6

Model Description

A IRES-iCre expression cassette was knocked into the Slc17a6 gene stop codon site.
Research Application：Cre recombinase tool; The glutamate transporter 2 gene (Vglut2/Slc17a6) is expressed in multiple brain regions. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and thalamus derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the retina of Slc17a6Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer derived from Slc17a6Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of Slc17a6Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, striatum and thalamus. TdTomato can also be detected in individual cells of the retinal ganglion cell layer and extranet layer, pituitary gland, heart, kidney, testis, epididymis, brown fat, thymus, spleen, stomach, skeletal muscle, intestine, colon, salivary gland and pancreas islet. Tdtomato expression can not be observed in the lung, liver or skin. (For more detailed information please contact our technical advisor.)


Publications

Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus–thalamus circuitry
References：PNAS

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