hAPOC3

Nomenclature

C57BL/6Smoc-Apoc3em1(hAPOC3)Smoc

Cat. NO.

NM-HU-225050

Strain State

Repository Live

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Gene Summary

Gene Symbol
Apoc3

Model Description

The endogenous mouse Apoc3 gene was replaced by human APOC3 gene.

Validation Data

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Fig1. Detection of APOC3 expression in liver by RT-PCR. 

Wild type: only one band at 196 bp with primers F1/R1(mApoc3); Homozygous: only one band at 219 bp with primers F2/R2(hAPOC3). Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig2. Detection of species-specific APOC3 expression in serum by ELISA. 

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

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Fig3. Monitoring of blood lipids levels in hAPOC3 mice (n=3 female and 3 male). 

Abbr. Hom, homozygous; WT, wild type.


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