NOD SCID

Nomenclature

NOD.Cg-Prkdcscid/NifdcSmoc

Cat. NO.

SM-019

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Prkdc

Model Description

The scid mutation has been transferred onto a diabetes-susceptible Non-Obese Diabetic (NOD) background. NOD-Scid mice do not develop diabetes, lack T and B cells, and are inherently immune deficient, making them good recipients for transplantation of human hematopoietic stem cells and human solid tumors. 


Validation Data

image.png

Fig1. Body weight growth curve of NOD SCID (n=168)

image.png

Fig 2. Detection of serum antibody subclasses in NOD SCID mice (8-week old, male).

image.png

Fig3. Complete deletion of T, B and NK cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of T, B and NK cells by FACS.

image.png

Fig4. Complete deletion of Monocytes, macrophages and DC cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of Monocytes, macrophages and DC cells by FACS.

image.pngFig5. Pathological examination of various tissues in NOD SCID mice. Thymus was absent in NOD SCID mice, and no significant pathologic abnormalities were found in the other tissues examined (8-week old, A males, B females).

屏幕截图 2024-01-17 152305.png

Fig6. Subcutaneous xenograft tumor growth in NOD SCID. 

image.png

Fig7. Blood routine tests in NOD SCID.

image.png

Fig8. Blood biochemistry in NOD SCID.

Table 1. NOD SCID xenograft cell lines

image.png


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more