Ighm/Ighd-KO

Nomenclature

C57BL/6Smoc-Ighmem1Ighdem1Smoc

Cat. NO.

NM-KO-200610

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol

Synonyms

Igm，muH，Igh6，Igh-6，Igh-M，AI326478，IgD，Igh-5

NCBI ID

16019

MGI ID

96448，96447

Ensembl ID

ENSMUSG00000076617，ENSMUSG00000104213

Pubmed

Human Ortholog

IGHM，IGHD

Model Description

Exon 1-6 of Ighm and exon 1-5 of Ighd gene was deleted to generate Ighm and Ighd knockout mice. Homozygous mutant mice lack mature B cells. It may be useful as a model for B cell immunodeficiency found in humans.
Research Application：Immune-related

Validation Data

image.png

Fig1. Confirmation of Ighm knockout and B cell development in blood in Ighm/Ighd-KO mice by FACS.

image.png

Fig2. T cell and NK cell lineages development in blood in Ighm/Ighd-KO mice by FACS.

image.png

Fig3. In vivo anti-tumor efficacy in Ighm/Ighd-KO mice bearing MC38 syngeneic tumors.

image.png

Fig4. The impact of B cell depeltion on the anti-tumor efficacy in Ighm/Ighd-KO mice bearing mPA6115 tumors (GEMM-derived homograft).

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more