hIL21/hIL21R
Nomenclature
C57BL/6Smoc-Il21tm1(hIL21)Il21rtm1(hIL21R)Smoc
Cat. NO.
NM-HU-220038
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
IL21
Gene Symbol
IL21R
Model Description
Validation Data
Fig 1. Detection of IL21 expression in splenocyte by RT-PCR.
Wild type: only one band at 272 bp with primers F1/R1 (mIl21);
Homozygous: only one band at 304 bp with primers F2/R2 (hIL21);
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig 2. Detection of hIL21 expression in culture supernatants of splenocyte by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. Splenocytes from C57BL/6 and homozygous hIL21/hIL21R dKI mice were stimulated with anti-mCD3 antibody in vitro.
Fig 3. Detection of IL21R expression on spleen-derived activated T cells and B cells in hIL21/hIL21R dKI mice.
Note. Splenocytes from C57BL/6 and homozygous hIL21/hIL21R dKI mice were stimulated with anti-mCD3 antibody in vitro.
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreOur vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
Learn more
