hIL2/hIL2RA

Nomenclature

C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

Cat. NO.

NM-HU-200275

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol

Synonyms

Il-2，I， CD25， Il2r， Ly-4， Ly-43

NCBI ID

16183，16184

MGI ID

96548，96549

Ensembl ID

ENSMUSG00000027720，ENSMUSG00000026770

Pubmed

Human Ortholog

IL-2，IL2RA

Model Description

hIL2(NM-HU-190048) was crossed with hIL2R(NM-HU-190064) to generate IhIL2/hIL2RA mice.

Validation Data

image.png

Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

image.png

Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).

image.png

Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).

image.png

Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).

image.png

Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more