Slc34a1-KO

Nomenclature

C57BL/6Smoc-Slc34a1em1Smoc

Cat. NO.

NM-KO-200642

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Slc34a1

Synonyms

Npt2， Npt2a， Slc17a2， NaPi-IIa

NCBI ID

20505

MGI ID

1345284

Ensembl ID

ENSMUSG00000021490

Pubmed

Slc34a1

Human Ortholog

SLC34A1

Model Description

Exon 3-6 of Slc34a1 gene was deleted to generate Slc34a1 knockout mice.
Research Application：Research on mineral absorption and synthesis of parathyroid hormone

Disease Connection

Hereditary Hypophosphatemic Rickets With Hypercalciuria

Phenotype(s)

MGI:4359221
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc34A3-KO(NM-KO-2105936) mice.

Reference(s)

Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K, Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8

hereditary hypophosphatemic rickets with hypercalciuria

Phenotype(s)

MGI:3029314

Reference(s)

Beck L, Karaplis AC, Amizuka N, Hewson AS, Ozawa H, Tenenhouse HS, Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5372-7

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