hF11
Nomenclature
C57BL/6Smoc-F11em1(hF11)/Smoc
Cat. NO.
NM-HU-210015
Strain State
Repository Live
Gene Summary
Gene Symbol
F11
Model Description
The endogenous mice F11 gene was replaced by human F11 gene
Validation Data
Fig1. Detection of F11 expression in liver by RT-PCR.
Wild type: only one band at 364 bp with primers F1/R1(mF11);Homozygous: only one band at 364 bp with primers F2/R2(hF11); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig 2. Detection of hF11 expression in plasma by ELISA (RayBiotech, ELH-CoagFXI-1).
Abbr. HO, homozygous; WT, wild type.
Fig3. Detection of hF11 expression in plasma by ELISA (Abcam, ab108834).
Abbr. HO, homozygous; WT, wild type.
Fig4. Prothrombinogen time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) in hF11 mice. A. 8-10 weeks of age; B. 10-12 weeks of age.
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