hCCR8(BALB/c)(2)
Nomenclature
BALB/cAnSmoc-Ccr8em(hCCR8)Smoc
Cat. NO.
NM-HU-220501
Strain State
Repository Live
Gene Summary
Gene Symbol
CCR8
Model Description
Validation Data
Fig1. Detection of hCCR8 expression on spleen-derived activated T cells and Tregs in hCCR8 KI mice.
*Splenocytes were activated by anti-mCD3/CD28 antibody in vivo.
Fig2. In vivo antitumor responses of anti-hCCR8 alone in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.
(A) Mean tumor growth curves upon treatment; (B) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor; (C) Expression of hCCR8 in spleen in hCCR8 (v2) mice bearing CT26 tumor.
Fig3. In vivo antitumor responses of anti-hCCR8 alone or in combination with anti-CTLA-4 in BALB/c hCCR8(v2) knockin mice engrafted with CT26 tumor.
(A) Mean tumor growth curves upon treatment; (B) Individual tumor growth curves upon treatment; (C) In vivo antitumor response of anti-hCCR8 in hCCR8 (v2) mice bearing CT26 tumor.
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreOur vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
Learn more
