Lepr-Flox

Nomenclature

C57BL/6Smoc-Leprem1(flox)Smoc

Cat. NO.

NM-CKO-200116

Strain State

Repository Live

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Gene Summary

Gene Symbol
Lepr

Synonyms

db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like

NCBI ID

16847

MGI ID

104993

Ensembl ID

ENSMUSG00000057722

Pubmed

Lepr

Human Ortholog

LEPR

Model Description

These mice carry loxP sites flanking exon 4 of Lepr gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Lepr gene.
Research Application：Research on Development Leptin signal transduction through JAK/STAT and MAPK cascade and peptide ligand binding receptor

Disease Connection

Polycystic Ovary Syndrome

Phenotype(s)

MGI:5471586
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Insr-Flox(NM-CKO-200189) and Pomc1-cre mice.

Reference(s)

Marino JS, Iler J, Dowling AR, Chua S, Bruning JC, Coppari R, Hill JW, Adipocyte dysfunction in a mouse model of polycystic ovary syndrome (PCOS): evidence of adipocyte hypertrophy and tissue-specific inflammation. PLoS One. 2012;7(10):e48643

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