Lepr-g.G109052T
Nomenclature
B6.129S-Leprtm1Smoc
Cat. NO.
NM-KI-00001
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Lepr
Model Description
A point mutation was introduced to exon 19 (c.109052 G>T) via a recombineering strategy. Homozygous mutants are hyperphagic, low-activity, poorly cold-adapted, sterile and have enhanced fat conversion.
Research Application：Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.
*Literature published using this strain should indicate: Lepr-g.G109052T mice (Cat. NO. NM-KI-00001) were purchased from Shanghai Model Organisms Center, Inc..
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
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