Cdk4-KO

Nomenclature

C57BL/6Smoc-Cdk4em1Smoc

Cat. NO.

NM-KO-190614

Strain State

Developing

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Gene Summary

Official Symbol
Cdk4

Model Description

Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.
Research Application:The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).

Disease Connection

Type 1 Diabetes Mellitus

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