Cdh1-Flox

Nomenclature

C57BL/6Smoc-Cdh1tm(flox)1Smoc

Cat. NO.

NM-CKO-18016

Strain State

Repository Live

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Gene Summary

Gene Symbol
Cdh1

Synonyms

Um; UVO; Ecad; ARC-1; E-cad; L-CAM; AA960649

NCBI ID

12550

MGI ID

88354

Ensembl ID

ENSMUSG00000000303

Pubmed

Cdh1

Human Ortholog

CDH1

Model Description

These mice carry loxP sites flanking exon3 of the Cdh1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Disease Connection

Stomach Cancer

Phenotype(s)

MGI:5634400
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Smad4-Flox(NM-CKO-18011)，P53-Flox(2)(NM-CKO-190067) and Pdx1-cre mice.

Reference(s)

Park JW, Jang SH, Park DM, Lim NJ, Deng C, Kim DY, Green JE, Kim HK, Cooperativity of E-cadherin and Smad4 Loss to Promote Diffuse-Type Gastric Adenocarcinoma and Metastasis. Mol Cancer Res. 2014 Aug;12(8):1088-99

Invasive Lobular Carcinoma

Phenotype(s)

MGI:6296606
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cdh1-Flox(NM-CKO-18016) and Wap-cre mice.

Reference(s)

Derksen PW, Braumuller TM, van der Burg E, Hornsveld M, Mesman E, Wesseling J, Krimpenfort P, Jonkers J, Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech. 2011 May-Jun;4(3):347-58

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