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Models

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Mice

hCD28

Strain Name:C57BL/6Smoc-Cd28em2(hCD28)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-190011

The endogenous mouse Cd28 gene was replaced by human CD28 gene.

Mice

H11-pT3(b)-hIL15-Flag

Strain Name:C57BL/6Smoc-Igs2em(pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA)Smoc
Strain State:Sperm cryopreservation | Cat. NO.:NM-KI-220128

pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA expression cassette was knocked into the the lgs2 (H11) locus.

Mice

hTLR8/Lyz2-DTREGFP

Strain Name:C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-200259

NM-KI-190041 was crossed with NM-HU-190044 to generate hTLR8/Lyz2-IRES-DTREGFP mice.

Mice

hCD38(2)

Strain Name:C57BL/6Smoc-Cd38em2(CD38)Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-190059

The endogenous mouse Cd38 gene was replaced by human CD38 gene. While hCD38 mice(Stock No.NM-HU-00113)have been pulled from shelves for some reasons.

Mice

h4-1BB(2)/hPD-1/hPD-L1

Strain Name:C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-210357

h4-1BB(2)(NM-HU-190077), hPD-L1(NM-HU-00062) and hPD-1(NM-HU-00015) was crossed together to generate h4-1BB(2)/hPD-1/hPD-L1 mice.

Mice

Rag2/IL2rg-KO/hSIRPA(2)/hCD47

Strain Name:C57BL/6Smoc-Sirpaem1(hSIRPA)Cd47em1(hCD47)Rag2em1Il2rgem1/Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-HU-2000019

The Rag2 and Il2rg genes of the hSIRPA(2)/hCD47 mouse were deleted.

Mice

Pten-KO

Strain Name:C57BL/6Smoc-Ptenem3Smoc
Strain State:Embryo cryopreservation | Cat. NO.:NM-KO-18002

Exon5 of Pten gene was deleted to generate Pten knockout mice.

Mice

Acta2-CreERT2

Strain Name:C57BL/6Smoc-Acta2em1(CreERT2-Wpre-polyA)Smoc
Strain State:Repository Live | Cat. NO.:NM-KI-200074

A CreERT2-Wpre-polyA expression cassette was knocked into the Acta2 gene start codon site.

Mice

hANGPTL3(4)

Strain Name:C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State:Repository Live | Cat. NO.:NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

B2m-KO(NMG)

Strain Name:NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State:Repository Live | Cat. NO.:NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

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